Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 659638..660437 Replicon chromosome
Accession NZ_CP101705
Organism Escherichia coli strain 035152

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NPL72_RS03225 Protein ID WP_000347251.1
Coordinates 659638..660102 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NPL72_RS03230 Protein ID WP_001307405.1
Coordinates 660102..660437 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPL72_RS03195 (654639) 654639..655073 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NPL72_RS03200 (655091) 655091..655969 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NPL72_RS03205 (655959) 655959..656738 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NPL72_RS03210 (656749) 656749..657222 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NPL72_RS03215 (657245) 657245..658525 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
NPL72_RS03220 (658774) 658774..659583 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NPL72_RS03225 (659638) 659638..660102 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NPL72_RS03230 (660102) 660102..660437 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NPL72_RS03235 (660586) 660586..662157 - 1572 WP_001273761.1 galactarate dehydratase -
NPL72_RS03240 (662532) 662532..663866 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
NPL72_RS03245 (663882) 663882..664652 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T252526 WP_000347251.1 NZ_CP101705:c660102-659638 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT252526 WP_001307405.1 NZ_CP101705:c660437-660102 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References