Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2587924..2588526 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag NOV91_RS12705 Protein ID WP_001159628.1
Coordinates 2587924..2588235 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NOV91_RS12710 Protein ID WP_000362050.1
Coordinates 2588236..2588526 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS12670 (2583037) 2583037..2583636 + 600 WP_000965702.1 glucose-1-phosphatase -
NOV91_RS12675 (2583630) 2583630..2584502 + 873 WP_000921423.1 virulence factor BrkB family protein -
NOV91_RS12680 (2584499) 2584499..2584936 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NOV91_RS12685 (2584981) 2584981..2585922 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NOV91_RS12690 (2585937) 2585937..2586383 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NOV91_RS12695 (2586380) 2586380..2586691 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NOV91_RS12700 (2586777) 2586777..2587706 - 930 WP_017441897.1 alpha/beta hydrolase -
NOV91_RS12705 (2587924) 2587924..2588235 + 312 WP_001159628.1 hypothetical protein Toxin
NOV91_RS12710 (2588236) 2588236..2588526 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NOV91_RS12715 (2588573) 2588573..2589502 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NOV91_RS12720 (2589499) 2589499..2590134 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NOV91_RS12725 (2590131) 2590131..2591033 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T252495 WP_001159628.1 NZ_CP101689:2587924-2588235 [Salmonella enterica subsp. enterica serovar Mbandaka]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT252495 WP_000362050.1 NZ_CP101689:2588236-2588526 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References