Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2035685..2036223 Replicon chromosome
Accession NZ_CP101689
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag NOV91_RS10090 Protein ID WP_001526148.1
Coordinates 2035685..2035960 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A3V4SM47
Locus tag NOV91_RS10095 Protein ID WP_017441598.1
Coordinates 2035963..2036223 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV91_RS10085 (2032892) 2032892..2035597 + 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -
NOV91_RS10090 (2035685) 2035685..2035960 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
NOV91_RS10095 (2035963) 2035963..2036223 - 261 WP_017441598.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NOV91_RS10100 (2036332) 2036332..2037351 - 1020 WP_017441599.1 RNA 3'-terminal phosphate cyclase -
NOV91_RS10105 (2037355) 2037355..2038569 - 1215 WP_017441600.1 RNA-splicing ligase RtcB -
NOV91_RS10110 (2038917) 2038917..2040470 - 1554 WP_017441601.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T252491 WP_001526148.1 NZ_CP101689:c2035960-2035685 [Salmonella enterica subsp. enterica serovar Mbandaka]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9460.83 Da        Isoelectric Point: 4.4734

>AT252491 WP_017441598.1 NZ_CP101689:c2036223-2035963 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGIDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SM47

References