Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3607908..3608635 Replicon chromosome
Accession NZ_CP101666
Organism Escherichia coli strain M171-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NO473_RS17580 Protein ID WP_130062357.1
Coordinates 3607908..3608222 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NO473_RS17585 Protein ID WP_000560266.1
Coordinates 3608219..3608635 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO473_RS17560 (3604066) 3604066..3605052 - 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -
NO473_RS17565 (3605131) 3605131..3605823 - 693 WP_000942548.1 vancomycin high temperature exclusion protein -
NO473_RS17570 (3605900) 3605900..3606403 - 504 WP_001333820.1 M48 family metallopeptidase -
NO473_RS17575 (3606488) 3606488..3607624 + 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
NO473_RS17580 (3607908) 3607908..3608222 + 315 WP_130062357.1 type II toxin-antitoxin system toxin HigB Toxin
NO473_RS17585 (3608219) 3608219..3608635 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
NO473_RS17590 (3608680) 3608680..3610698 - 2019 WP_000121433.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
NO473_RS17595 (3611124) 3611124..3613475 - 2352 WP_130062358.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12129.14 Da        Isoelectric Point: 9.9845

>T252471 WP_130062357.1 NZ_CP101666:3607908-3608222 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKYYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT252471 WP_000560266.1 NZ_CP101666:3608219-3608635 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References