Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 153024..153526 Replicon chromosome
Accession NZ_CP101666
Organism Escherichia coli strain M171-1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NO473_RS00670 Protein ID WP_000767829.1
Coordinates 153272..153526 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NO473_RS00665 Protein ID WP_001610372.1
Coordinates 153024..153275 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO473_RS00640 (148202) 148202..149269 - 1068 WP_000080141.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NO473_RS00645 (149269) 149269..150339 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
NO473_RS00650 (150336) 150336..151640 - 1305 WP_001367667.1 histidinol dehydrogenase -
NO473_RS00655 (151646) 151646..152545 - 900 WP_000131792.1 ATP phosphoribosyltransferase -
NO473_RS00660 (152691) 152691..152741 - 51 WP_001364200.1 his operon leader peptide -
NO473_RS00665 (153024) 153024..153275 + 252 WP_001610372.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NO473_RS00670 (153272) 153272..153526 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NO473_RS00675 (153609) 153609..154433 + 825 WP_000754737.1 SDR family oxidoreductase -
NO473_RS00680 (154479) 154479..155408 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NO473_RS00685 (155623) 155623..155685 + 63 WP_010723108.1 membrane protein YoeI -
NO473_RS00690 (155675) 155675..157033 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NO473_RS00695 (157212) 157212..158270 + 1059 WP_000492333.1 thiosulfate utilization transporter TsuA/YeeE -
NO473_RS00700 (158284) 158284..158511 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T252456 WP_000767829.1 NZ_CP101666:153272-153526 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9289.55 Da        Isoelectric Point: 4.7954

>AT252456 WP_001610372.1 NZ_CP101666:153024-153275 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLIDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References