Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6196089..6196684 Replicon chromosome
Accession NZ_CP101656
Organism Pseudomonas aeruginosa strain L1a

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag MBA02_RS28675 Protein ID WP_003113526.1
Coordinates 6196406..6196684 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MBA02_RS28670 Protein ID WP_003113527.1
Coordinates 6196089..6196394 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA02_RS28640 (MBA02_028640) 6191202..6191492 - 291 WP_033992920.1 DUF5447 family protein -
MBA02_RS28645 (MBA02_028645) 6191704..6191976 - 273 WP_003115921.1 hypothetical protein -
MBA02_RS28650 (MBA02_028650) 6192102..6192371 + 270 WP_071536122.1 hypothetical protein -
MBA02_RS28655 (MBA02_028655) 6192506..6193603 + 1098 WP_169917322.1 protein phosphatase 2C domain-containing protein -
MBA02_RS28660 (MBA02_028660) 6193606..6194655 + 1050 WP_003113529.1 serine/threonine-protein kinase -
MBA02_RS28665 (MBA02_028665) 6194652..6195725 + 1074 WP_003113528.1 serine/threonine-protein kinase -
MBA02_RS28670 (MBA02_028670) 6196089..6196394 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
MBA02_RS28675 (MBA02_028675) 6196406..6196684 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MBA02_RS28680 (MBA02_028680) 6196737..6196865 - 129 Protein_5661 integrase -
MBA02_RS28685 (MBA02_028685) 6197013..6199241 + 2229 WP_003113525.1 TonB-dependent receptor -
MBA02_RS28690 (MBA02_028690) 6199311..6199958 - 648 WP_003095021.1 carbonate dehydratase -
MBA02_RS28695 (MBA02_028695) 6200020..6201258 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T252453 WP_003113526.1 NZ_CP101656:c6196684-6196406 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT252453 WP_003113527.1 NZ_CP101656:c6196394-6196089 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References