Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 155544..156298 Replicon chromosome
Accession NZ_CP101647
Organism Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag NOQ94_RS00730 Protein ID WP_000558166.1
Coordinates 155544..155855 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NOQ94_RS00735 Protein ID WP_001259011.1
Coordinates 155852..156298 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ94_RS00700 (151202) 151202..152104 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NOQ94_RS00705 (152101) 152101..152736 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NOQ94_RS00710 (152733) 152733..153662 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NOQ94_RS00715 (153709) 153709..153999 - 291 WP_000362052.1 DNA-binding transcriptional regulator -
NOQ94_RS00720 (154000) 154000..154311 - 312 WP_023138876.1 hypothetical protein -
NOQ94_RS00725 (154529) 154529..155458 + 930 WP_001127698.1 alpha/beta hydrolase -
NOQ94_RS00730 (155544) 155544..155855 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
NOQ94_RS00735 (155852) 155852..156298 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
NOQ94_RS00740 (156313) 156313..157254 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NOQ94_RS00745 (157299) 157299..157736 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NOQ94_RS00750 (157733) 157733..158605 - 873 WP_000921423.1 virulence factor BrkB family protein -
NOQ94_RS00755 (158599) 158599..159198 - 600 WP_000965695.1 glucose-1-phosphatase -
NOQ94_RS00760 (159389) 159389..160192 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
NOQ94_RS00765 (160226) 160226..161122 - 897 WP_001520529.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T252414 WP_000558166.1 NZ_CP101647:155544-155855 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp


Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT252414 WP_001259011.1 NZ_CP101647:155852-156298 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90


Antitoxin

Source ID Structure

References