Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 153709..154311 Replicon chromosome
Accession NZ_CP101647
Organism Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)


Gene name higB Uniprot ID A0A603E470
Locus tag NOQ94_RS00720 Protein ID WP_023138876.1
Coordinates 154000..154311 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NOQ94_RS00715 Protein ID WP_000362052.1
Coordinates 153709..153999 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ94_RS00700 (151202) 151202..152104 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NOQ94_RS00705 (152101) 152101..152736 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NOQ94_RS00710 (152733) 152733..153662 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NOQ94_RS00715 (153709) 153709..153999 - 291 WP_000362052.1 DNA-binding transcriptional regulator Antitoxin
NOQ94_RS00720 (154000) 154000..154311 - 312 WP_023138876.1 hypothetical protein Toxin
NOQ94_RS00725 (154529) 154529..155458 + 930 WP_001127698.1 alpha/beta hydrolase -
NOQ94_RS00730 (155544) 155544..155855 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NOQ94_RS00735 (155852) 155852..156298 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NOQ94_RS00740 (156313) 156313..157254 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NOQ94_RS00745 (157299) 157299..157736 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NOQ94_RS00750 (157733) 157733..158605 - 873 WP_000921423.1 virulence factor BrkB family protein -
NOQ94_RS00755 (158599) 158599..159198 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12356.30 Da        Isoelectric Point: 9.4460

>T252413 WP_023138876.1 NZ_CP101647:c154311-154000 [Salmonella enterica subsp. enterica serovar Kentucky]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10970.65 Da        Isoelectric Point: 11.0303

>AT252413 WP_000362052.1 NZ_CP101647:c153999-153709 [Salmonella enterica subsp. enterica serovar Kentucky]
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A603E470

Antitoxin

Source ID Structure

References