252412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2718115..2718637 Replicon chromosome
Accession NZ_CP101643
Organism Lacticaseibacillus rhamnosus strain CLK 101

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag NOS86_RS12550 Protein ID WP_005687756.1
Coordinates 2718377..2718637 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag NOS86_RS12545 Protein ID WP_005687754.1
Coordinates 2718115..2718384 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOS86_RS12525 (NOS86_12525) 2713701..2714270 - 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -
NOS86_RS12530 (NOS86_12530) 2714283..2714793 - 511 Protein_2428 transcriptional regulator GutM -
NOS86_RS12535 (NOS86_12535) 2714794..2716662 - 1869 WP_014571687.1 HTH domain-containing protein -
NOS86_RS12540 (NOS86_12540) 2716689..2717489 - 801 WP_005690776.1 SDR family oxidoreductase -
NOS86_RS12545 (NOS86_12545) 2718115..2718384 + 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NOS86_RS12550 (NOS86_12550) 2718377..2718637 + 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
NOS86_RS12555 (NOS86_12555) 2718848..2719576 - 729 WP_014571689.1 L-ribulose-5-phosphate 4-epimerase -
NOS86_RS12560 (NOS86_12560) 2719773..2720594 + 822 WP_005690770.1 Cof-type HAD-IIB family hydrolase -
NOS86_RS12565 (NOS86_12565) 2720661..2721548 - 888 WP_014571690.1 L-ribulose-5-phosphate 3-epimerase -
NOS86_RS12570 (NOS86_12570) 2721733..2722512 - 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
NOS86_RS12575 (NOS86_12575) 2722580..2723221 - 642 WP_005690763.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T252412 WP_005687756.1 NZ_CP101643:2718377-2718637 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT252412 WP_005687754.1 NZ_CP101643:2718115-2718384 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References