252409

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 512788..513273 Replicon chromosome
Accession NZ_CP101643
Organism Lacticaseibacillus rhamnosus strain CLK 101

Toxin (Protein)


Gene name yafQ Uniprot ID C2K0Y1
Locus tag NOS86_RS02425 Protein ID WP_005691636.1
Coordinates 512788..512973 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A508YYT1
Locus tag NOS86_RS02430 Protein ID WP_014571130.1
Coordinates 513001..513273 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOS86_RS02405 (NOS86_02405) 507795..508484 + 690 WP_005691628.1 rhomboid family intramembrane serine protease -
NOS86_RS02410 (NOS86_02410) 508976..509584 - 609 WP_005691630.1 hypothetical protein -
NOS86_RS02415 (NOS86_02415) 510031..510906 + 876 WP_024305787.1 XRE family transcriptional regulator -
NOS86_RS02420 (NOS86_02420) 511149..512564 - 1416 WP_005691634.1 exonuclease domain-containing protein -
NOS86_RS02425 (NOS86_02425) 512788..512973 - 186 WP_005691636.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
NOS86_RS02430 (NOS86_02430) 513001..513273 - 273 WP_014571130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NOS86_RS02435 (NOS86_02435) 513835..514083 + 249 WP_005691639.1 hypothetical protein -
NOS86_RS02440 (NOS86_02440) 514326..514619 + 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
NOS86_RS02445 (NOS86_02445) 514701..515864 + 1164 WP_005691640.1 MFS transporter -
NOS86_RS02450 (NOS86_02450) 516018..516593 + 576 WP_014571131.1 DNA-3-methyladenine glycosylase I -
NOS86_RS02455 (NOS86_02455) 516715..516933 + 219 WP_005691646.1 hypothetical protein -
NOS86_RS02460 (NOS86_02460) 517062..517943 - 882 WP_005684263.1 class II fructose-1,6-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-57)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-65)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6781.86 Da        Isoelectric Point: 7.4698

>T252409 WP_005691636.1 NZ_CP101643:c512973-512788 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE

Download         Length: 186 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10005.62 Da        Isoelectric Point: 9.5939

>AT252409 WP_014571130.1 NZ_CP101643:c513273-513001 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2J6C9

Antitoxin

Source ID Structure
AlphaFold DB A0A508YYT1

References