Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 352483..353158 Replicon chromosome
Accession NC_015563
Organism Delftia sp. Cs1-4

Toxin (Protein)


Gene name higB Uniprot ID F6AKY9
Locus tag DELCS14_RS01510 Protein ID WP_013800178.1
Coordinates 352483..352866 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID F6AKZ0
Locus tag DELCS14_RS01515 Protein ID WP_013800179.1
Coordinates 352847..353158 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DELCS14_RS01495 349787..350518 + 732 WP_013800176.1 TorF family putative porin -
DELCS14_RS01500 350542..350880 + 339 WP_012202241.1 P-II family nitrogen regulator -
DELCS14_RS01505 350912..352285 + 1374 WP_170962109.1 ammonium transporter -
DELCS14_RS01510 352483..352866 + 384 WP_013800178.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DELCS14_RS01515 352847..353158 + 312 WP_013800179.1 helix-turn-helix transcriptional regulator Antitoxin
DELCS14_RS01520 353295..354434 + 1140 WP_013800180.1 glycolate oxidase subunit GlcE -
DELCS14_RS01525 354460..355242 + 783 WP_012202244.1 DUF1275 domain-containing protein -
DELCS14_RS01530 355304..356554 + 1251 WP_013800181.1 glycolate oxidase subunit GlcF -
DELCS14_RS01535 356639..357505 + 867 WP_034397802.1 ProQ/FinO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14752.44 Da        Isoelectric Point: 5.2260

>T25240 WP_013800178.1 NC_015563:352483-352866 [Delftia sp. Cs1-4]
MTQPWEVEYTDELGDWWADLTQAEQESIDASVRLLEARGPNLGYPHTSGIGRSRHPHMRELRVQHEGRPYRLLYAFDPRR
CAILLIGGDKTGDGRWYEVHVPIADRLYDTHLETLQKEGRIDGQEIQ

Download         Length: 384 bp

>T25240 NC_015563:352483-352866 [Delftia sp. Cs1-4]
ATGACCCAACCCTGGGAGGTGGAGTACACCGACGAGCTTGGCGACTGGTGGGCTGATCTGACGCAGGCCGAGCAGGAGTC
CATCGACGCATCGGTGCGTCTGCTGGAGGCAAGAGGGCCGAATCTCGGATATCCCCATACGTCCGGCATCGGGCGTTCCA
GGCATCCGCACATGCGTGAGCTTCGGGTGCAACATGAGGGACGGCCTTACCGGCTGCTTTACGCGTTCGATCCGCGCCGC
TGCGCAATCTTGCTGATCGGCGGCGACAAAACGGGCGACGGCCGCTGGTATGAGGTGCATGTACCCATTGCCGATCGGCT
GTACGACACCCACCTCGAAACCCTGCAAAAGGAAGGACGAATCGATGGCCAGGAAATTCAGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11803.60 Da        Isoelectric Point: 9.8220

>AT25240 WP_013800179.1 NC_015563:352847-353158 [Delftia sp. Cs1-4]
MARKFSELRARMSPEAQSRAAARAEAMLVEMQLQELRKARNVTQVEVARAMNVEQASISKLERREDMYVSTLREYVRALG
GELRLVASFPDADIQVHPFEPLR

Download         Length: 312 bp

>AT25240 NC_015563:352847-353158 [Delftia sp. Cs1-4]
ATGGCCAGGAAATTCAGTGAACTGCGCGCCAGGATGTCGCCTGAGGCACAGTCCCGGGCCGCCGCGCGGGCCGAGGCCAT
GCTGGTGGAAATGCAGCTCCAGGAATTGCGCAAGGCCCGCAACGTGACACAGGTCGAAGTGGCCAGGGCCATGAACGTGG
AGCAAGCATCCATCTCCAAGCTGGAGCGCCGCGAGGACATGTACGTGAGCACGCTGCGCGAGTACGTCCGTGCGCTGGGC
GGCGAGCTGAGGCTGGTCGCCTCGTTTCCCGACGCCGACATCCAGGTCCATCCTTTCGAGCCTCTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A031HZS7

Antitoxin

Source ID Structure
AlphaFold DB A0A031I0J9

References