Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 22643..23300 Replicon plasmid pA84-2
Accession NZ_CP101597
Organism Cronobacter dublinensis strain CFSA A84

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NNQ27_RS22680 Protein ID WP_275886456.1
Coordinates 22929..23300 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NNQ27_RS22675 Protein ID WP_105693805.1
Coordinates 22643..22942 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNQ27_RS22655 (NNQ27_22655) 18256..19188 - 933 WP_275886479.1 hypothetical protein -
NNQ27_RS22660 (NNQ27_22660) 21185..21457 + 273 WP_275886453.1 hypothetical protein -
NNQ27_RS22665 (NNQ27_22665) 21481..21750 + 270 WP_275886454.1 hypothetical protein -
NNQ27_RS22670 (NNQ27_22670) 21796..22020 - 225 WP_275886455.1 hypothetical protein -
NNQ27_RS22675 (NNQ27_22675) 22643..22942 - 300 WP_105693805.1 XRE family transcriptional regulator Antitoxin
NNQ27_RS22680 (NNQ27_22680) 22929..23300 - 372 WP_275886456.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NNQ27_RS22685 (NNQ27_22685) 23475..23736 + 262 Protein_25 hypothetical protein -
NNQ27_RS22690 (NNQ27_22690) 24953..25756 - 804 WP_105648991.1 DUF4225 domain-containing protein -
NNQ27_RS22695 (NNQ27_22695) 26156..26488 + 333 WP_275886457.1 hypothetical protein -
NNQ27_RS22700 (NNQ27_22700) 27294..27965 + 672 WP_175613492.1 hypothetical protein -
NNQ27_RS22705 (NNQ27_22705) 27967..28263 + 297 WP_275886458.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38910 38910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14100.88 Da        Isoelectric Point: 4.4512

>T252372 WP_275886456.1 NZ_CP101597:c23300-22929 [Cronobacter dublinensis]
MAWEIETRILFDTWFEEQEEDVQEEILAYFEILEGEGPNLGRPHVDSVNGSDYTNMKELRVQVGGHPYRLFFAFDPARKA
IVLCGGNKKGLVEKDFYKKMIKIADAEYASHLKSPEVKEDGDA

Download         Length: 372 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10841.72 Da        Isoelectric Point: 10.3986

>AT252372 WP_105693805.1 NZ_CP101597:c22942-22643 [Cronobacter dublinensis]
MATLKEMMAKRSPESRARIAARTAEIRQEITLAKLRDELNVSQTQLAAVLGVSQPSIVKLEKVENDPKLSTLKRYVTALG
GELALDVTLPDGKRIALTL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References