Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2844079..2844724 Replicon chromosome
Accession NZ_CP101591
Organism Cronobacter dublinensis strain CFSA A14

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NMY27_RS13670 Protein ID WP_007750250.1
Coordinates 2844362..2844724 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMY27_RS13665 Protein ID WP_007750247.1
Coordinates 2844079..2844375 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY27_RS13655 (NMY27_13645) 2841737..2842585 - 849 WP_038887202.1 DNA-3-methyladenine glycosylase 2 -
NMY27_RS13660 (NMY27_13650) 2842721..2844073 + 1353 WP_105632043.1 molecular chaperone -
NMY27_RS13665 (NMY27_13655) 2844079..2844375 - 297 WP_007750247.1 XRE family transcriptional regulator Antitoxin
NMY27_RS13670 (NMY27_13660) 2844362..2844724 - 363 WP_007750250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMY27_RS13675 (NMY27_13665) 2844954..2846195 + 1242 WP_275875806.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
NMY27_RS13680 (NMY27_13670) 2846195..2849317 + 3123 WP_275875807.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14023.13 Da        Isoelectric Point: 9.8453

>T252353 WP_007750250.1 NZ_CP101591:c2844724-2844362 [Cronobacter dublinensis]
MTWTVIFTPRFYEWYQQQPEGLQDRIAALLWNLRHSGPLVGRPLVDTIKGSQIPNLKELRVQYGGSPWRVFFAFDPTRQA
VVLCAGNKRGHKDFYKTLIRQAEEAFFLHLQIMESKNENA

Download         Length: 363 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10851.77 Da        Isoelectric Point: 5.8787

>AT252353 WP_007750247.1 NZ_CP101591:c2844375-2844079 [Cronobacter dublinensis]
MKTLDDVMAAFTPERQAEILRMADEIALEHGLPRLREERAFSQQQLAALMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLVELPEGSKVIPV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References