Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 64924..65350 | Replicon | plasmid p29_2 |
| Accession | NZ_CP101569 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain KP29 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | NMY30_RS28675 | Protein ID | WP_001372321.1 |
| Coordinates | 64924..65049 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 65126..65350 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NMY30_RS28645 (60535) | 60535..60807 | - | 273 | Protein_77 | transposase | - |
| NMY30_RS28655 (61789) | 61789..62811 | - | 1023 | WP_000361404.1 | helicase UvrD | - |
| NMY30_RS28660 (62796) | 62796..63191 | - | 396 | Protein_80 | ATP-dependent endonuclease | - |
| NMY30_RS28665 (63254) | 63254..63958 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| NMY30_RS28670 (64309) | 64309..64605 | + | 297 | Protein_82 | hypothetical protein | - |
| NMY30_RS28675 (64924) | 64924..65049 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| NMY30_RS28680 (64991) | 64991..65140 | - | 150 | Protein_84 | plasmid maintenance protein Mok | - |
| - (65126) | 65126..65350 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (65126) | 65126..65350 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (65126) | 65126..65350 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (65126) | 65126..65350 | - | 225 | NuclAT_0 | - | Antitoxin |
| NMY30_RS28685 (65362) | 65362..66081 | - | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
| NMY30_RS28690 (66078) | 66078..66512 | - | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| NMY30_RS28695 (66581) | 66581..68604 | - | 2024 | Protein_87 | ParB/RepB/Spo0J family partition protein | - |
| NMY30_RS28700 (68665) | 68665..68898 | - | 234 | WP_000006003.1 | DUF905 family protein | - |
| NMY30_RS28705 (68956) | 68956..69483 | - | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
| NMY30_RS28710 (69785) | 69785..70240 | + | 456 | Protein_90 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaSHV-12 / blaKPC-2 / rmtB / fosA3 / blaCTX-M-65 / catA2 | - | 1..138059 | 138059 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T252337 WP_001372321.1 NZ_CP101569:c65049-64924 [Klebsiella pneumoniae subsp. pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
Antitoxin
Download Length: 225 bp
>AT252337 NZ_CP101569:c65350-65126 [Klebsiella pneumoniae subsp. pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
