Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 782598..783373 Replicon chromosome
Accession NZ_CP101554
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP72

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NMY33_RS03920 Protein ID WP_004150910.1
Coordinates 782888..783373 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NMY33_RS03915 Protein ID WP_004150912.1
Coordinates 782598..782891 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY33_RS03895 (NMY33_03895) 777806..778408 - 603 WP_002916735.1 short chain dehydrogenase -
NMY33_RS03900 (NMY33_03900) 778506..779417 + 912 WP_004188550.1 LysR family transcriptional regulator -
NMY33_RS03905 (NMY33_03905) 779418..780566 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NMY33_RS03910 (NMY33_03910) 780577..781953 - 1377 WP_004217775.1 cystathionine beta-synthase -
NMY33_RS03915 (NMY33_03915) 782598..782891 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NMY33_RS03920 (NMY33_03920) 782888..783373 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NMY33_RS03925 (NMY33_03925) 784077..784670 + 594 WP_004188553.1 hypothetical protein -
NMY33_RS03930 (NMY33_03930) 784767..784983 + 217 Protein_771 transposase -
NMY33_RS03935 (NMY33_03935) 785589..786461 + 873 WP_004188557.1 ParA family protein -
NMY33_RS03940 (NMY33_03940) 786461..786844 + 384 WP_004150906.1 hypothetical protein -
NMY33_RS03945 (NMY33_03945) 786837..788204 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 784767..784919 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T252279 WP_004150910.1 NZ_CP101554:782888-783373 [Klebsiella pneumoniae subsp. pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT252279 WP_004150912.1 NZ_CP101554:782598-782891 [Klebsiella pneumoniae subsp. pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References