Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5341619..5342214 Replicon chromosome
Accession NZ_CP101540
Organism Pseudomonas aeruginosa strain D-2

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NNL25_RS24890 Protein ID WP_003113526.1
Coordinates 5341936..5342214 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NNL25_RS24885 Protein ID WP_003099268.1
Coordinates 5341619..5341924 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL25_RS24865 (NNL25_24835) 5337104..5337439 + 336 WP_255866659.1 hypothetical protein -
NNL25_RS24870 (NNL25_24840) 5337971..5339737 - 1767 WP_023087829.1 anti-phage dCTP deaminase -
NNL25_RS24875 (NNL25_24845) 5339994..5340656 - 663 WP_023087830.1 restriction endonuclease -
NNL25_RS24880 (NNL25_24850) 5340880..5341293 - 414 WP_049231965.1 hypothetical protein -
NNL25_RS24885 (NNL25_24855) 5341619..5341924 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
NNL25_RS24890 (NNL25_24860) 5341936..5342214 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NNL25_RS24895 (NNL25_24865) 5342267..5342395 - 129 Protein_4918 integrase -
NNL25_RS24900 (NNL25_24870) 5342543..5344771 + 2229 WP_003099265.1 TonB-dependent receptor -
NNL25_RS24905 (NNL25_24875) 5344841..5345488 - 648 WP_003095021.1 carbonate dehydratase -
NNL25_RS24910 (NNL25_24880) 5345550..5346788 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T252236 WP_003113526.1 NZ_CP101540:c5342214-5341936 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT252236 WP_003099268.1 NZ_CP101540:c5341924-5341619 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References