Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2753580..2754102 Replicon chromosome
Accession NZ_CP101538
Organism Lacticaseibacillus rhamnosus strain HN067

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag NNM43_RS12855 Protein ID WP_005687756.1
Coordinates 2753842..2754102 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag NNM43_RS12850 Protein ID WP_005687754.1
Coordinates 2753580..2753849 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNM43_RS12830 (NNM43_12870) 2749167..2749736 - 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -
NNM43_RS12835 (NNM43_12875) 2749749..2750258 - 510 WP_005687749.1 transcriptional regulator GutM -
NNM43_RS12840 (NNM43_12880) 2750259..2752127 - 1869 WP_005687750.1 helix-turn-helix domain-containing protein -
NNM43_RS12845 (NNM43_12885) 2752154..2752954 - 801 WP_005687752.1 SDR family oxidoreductase -
NNM43_RS12850 (NNM43_12890) 2753580..2753849 + 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NNM43_RS12855 (NNM43_12895) 2753842..2754102 + 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
NNM43_RS12860 (NNM43_12900) 2754313..2755041 - 729 WP_005687757.1 L-ribulose-5-phosphate 4-epimerase -
NNM43_RS12865 (NNM43_12905) 2755238..2756059 + 822 WP_005687759.1 Cof-type HAD-IIB family hydrolase -
NNM43_RS12870 (NNM43_12910) 2756126..2757013 - 888 WP_005687761.1 L-ribulose-5-phosphate 3-epimerase -
NNM43_RS12875 (NNM43_12915) 2757197..2757976 - 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
NNM43_RS12880 (NNM43_12920) 2758044..2758685 - 642 WP_005687764.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T252228 WP_005687756.1 NZ_CP101538:2753842-2754102 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT252228 WP_005687754.1 NZ_CP101538:2753580-2753849 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References