Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3002502..3003092 Replicon chromosome
Accession NC_015510
Organism Haliscomenobacter hydrossis DSM 1100

Toxin (Protein)


Gene name graT Uniprot ID F4KV76
Locus tag HALHY_RS11675 Protein ID WP_013764752.1
Coordinates 3002502..3002783 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HALHY_RS11680 Protein ID WP_013764753.1
Coordinates 3002793..3003092 (+) Length 100 a.a.

Genomic Context

HALHY_RS11655HALHY_RS11660HALHY_RS11665HALHY_RS11670HALHY_RS11675HALHY_RS11680HALHY_RS11685HALHY_RS11690HALHY_RS11700HALHY_RS11705HALHY_RS11710
Location: 2998003..2998764 (762 bp)
Type: Others
Protein ID: WP_013764747.1
Location: 2998833..2999567 (735 bp)
Type: Others
Protein ID: WP_013764748.1
Location: 2999774..3000355 (582 bp)
Type: Others
Protein ID: WP_013764749.1
Location: 3000483..3002321 (1839 bp)
Type: Others
Protein ID: WP_013764750.1
Location: 3002502..3002783 (282 bp)
Type: Toxin
Protein ID: WP_013764752.1
Location: 3002793..3003092 (300 bp)
Type: Antitoxin
Protein ID: WP_013764753.1
Location: 3003224..3004222 (999 bp)
Type: Others
Protein ID: WP_013764754.1
Location: 3004361..3006190 (1830 bp)
Type: Others
Protein ID: WP_044233652.1
Location: 3006536..3006751 (216 bp)
Type: Others
Protein ID: WP_013764756.1
Location: 3006879..3007355 (477 bp)
Type: Others
Protein ID: WP_044233654.1
Location: 3007376..3007603 (228 bp)
Type: Others
Protein ID: WP_044233656.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HALHY_RS116552998003..2998764+762WP_013764747.1LytTR family DNA-binding domain-containing protein-
HALHY_RS116602998833..2999567+735WP_013764748.1DUF2490 domain-containing protein-
HALHY_RS116652999774..3000355+582WP_013764749.1OmpH family outer membrane protein-
HALHY_RS116703000483..3002321+1839WP_013764750.1phosphoenolpyruvate carboxykinase (GTP)-
HALHY_RS116753002502..3002783+282WP_013764752.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HALHY_RS116803002793..3003092+300WP_013764753.1HigA family addiction module antidote proteinAntitoxin
HALHY_RS116853003224..3004222+999WP_013764754.1virulence RhuM family protein-
HALHY_RS116903004361..3006190+1830WP_044233652.1ABC transporter ATP-binding protein/permease-
HALHY_RS117003006536..3006751+216WP_013764756.1hypothetical protein-
HALHY_RS117053006879..3007355+477WP_044233654.1hypothetical protein-
HALHY_RS117103007376..3007603-228WP_044233656.1DUF433 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11227.87 Da        Isoelectric Point: 9.9272

>T25222 WP_013764752.1 NC_015510:3002502-3002783 [Haliscomenobacter hydrossis DSM 1100]
MIKSFADKETEKIWNGSYSKKFPHDIQPVSRRKLRMINSAQDIEDLRIPPGNRLEKLKGDLKDFWSIRINNQWRIIFKWE
DNNALEVQIIDYH

Download         Length: 282 bp

>T25222 NC_015510:3002502-3002783 [Haliscomenobacter hydrossis DSM 1100]
ATGATTAAAAGCTTTGCAGATAAGGAAACTGAAAAAATTTGGAATGGATCTTACTCCAAAAAGTTTCCCCATGACATCCA
ACCCGTGTCAAGAAGAAAGCTCAGAATGATCAACAGTGCACAAGACATTGAAGACTTACGAATACCTCCGGGAAATAGAT
TAGAAAAGCTGAAAGGAGACTTGAAGGATTTCTGGAGCATTCGAATCAACAACCAGTGGCGGATCATCTTCAAATGGGAA
GACAACAATGCACTGGAAGTCCAAATCATTGACTATCATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11285.15 Da        Isoelectric Point: 5.7134

>AT25222 WP_013764753.1 NC_015510:3002793-3003092 [Haliscomenobacter hydrossis DSM 1100]
MEKLPNIHPGEILLEEFLLPMHISQYKLAKDLMIPQTRVSEIVKRKRRITADTALRLSKYFGTSAKFWLGLQDDYDLEES
GNLLAAELQAIPEAMPSIS

Download         Length: 300 bp

>AT25222 NC_015510:3002793-3003092 [Haliscomenobacter hydrossis DSM 1100]
ATGGAAAAATTACCCAACATCCACCCCGGCGAGATTCTCCTTGAAGAATTCCTCCTCCCCATGCATATCAGTCAATACAA
ACTGGCCAAAGACCTGATGATTCCCCAAACGAGAGTCAGTGAAATTGTAAAAAGAAAACGGCGCATCACTGCTGATACTG
CTTTACGGTTGAGCAAATACTTTGGTACCTCGGCTAAATTTTGGCTTGGACTTCAAGATGATTATGATTTGGAGGAGTCT
GGAAATTTGCTGGCCGCAGAACTACAGGCTATTCCTGAGGCTATGCCTTCTATTTCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBF4KV76

Antitoxin

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Source
ID
Structure
No matching records found

References