Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3655068..3655609 Replicon chromosome
Accession NZ_CP101513
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag MOO21_RS17740 Protein ID WP_000615980.1
Coordinates 3655331..3655609 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag MOO21_RS17735 Protein ID WP_000729707.1
Coordinates 3655068..3655328 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS17715 (3650835) 3650835..3651620 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
MOO21_RS17720 (3651592) 3651592..3653304 + 1713 Protein_3467 flagellar biosynthesis protein FlhA -
MOO21_RS17725 (3653436) 3653436..3653933 - 498 WP_000006245.1 REP-associated tyrosine transposase RayT -
MOO21_RS17730 (3654109) 3654109..3654882 - 774 WP_000543885.1 C40 family peptidase -
MOO21_RS17735 (3655068) 3655068..3655328 + 261 WP_000729707.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
MOO21_RS17740 (3655331) 3655331..3655609 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
MOO21_RS17745 (3655765) 3655765..3656505 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
MOO21_RS17750 (3656476) 3656476..3657243 - 768 WP_000333380.1 class II glutamine amidotransferase -
MOO21_RS17755 (3657449) 3657449..3658027 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T252177 WP_000615980.1 NZ_CP101513:3655331-3655609 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9421.80 Da        Isoelectric Point: 5.0758

>AT252177 WP_000729707.1 NZ_CP101513:3655068-3655328 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKTKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure

References