252168

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1774202..1774704 Replicon chromosome
Accession NZ_CP101513
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag MOO21_RS08415 Protein ID WP_000767829.1
Coordinates 1774450..1774704 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag MOO21_RS08410 Protein ID WP_001259255.1
Coordinates 1774202..1774453 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS08385 (1769380) 1769380..1770447 - 1068 WP_000080102.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
MOO21_RS08390 (1770447) 1770447..1771517 - 1071 WP_000108940.1 histidinol-phosphate transaminase -
MOO21_RS08395 (1771514) 1771514..1772818 - 1305 WP_247193854.1 histidinol dehydrogenase -
MOO21_RS08400 (1772824) 1772824..1773723 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
MOO21_RS08405 (1773869) 1773869..1773919 - 51 WP_001364200.1 his operon leader peptide -
MOO21_RS08410 (1774202) 1774202..1774453 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
MOO21_RS08415 (1774450) 1774450..1774704 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
MOO21_RS08420 (1774787) 1774787..1775611 + 825 WP_000754749.1 SDR family oxidoreductase -
MOO21_RS08425 (1775657) 1775657..1776586 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
MOO21_RS08430 (1776801) 1776801..1776863 + 63 WP_010723108.1 membrane protein YoeI -
MOO21_RS08435 (1776853) 1776853..1778211 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
MOO21_RS08440 (1778390) 1778390..1779448 + 1059 WP_000492315.1 thiosulfate utilization transporter TsuA/YeeE -
MOO21_RS08445 (1779462) 1779462..1779689 + 228 WP_000985280.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T252168 WP_000767829.1 NZ_CP101513:1774450-1774704 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT252168 WP_001259255.1 NZ_CP101513:1774202-1774453 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References