252165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 732218..732911 Replicon chromosome
Accession NZ_CP101513
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MOO21_RS03560 Protein ID WP_000415584.1
Coordinates 732218..732514 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MOO21_RS03565 Protein ID WP_000650107.1
Coordinates 732516..732911 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS03525 (727306) 727306..727620 - 315 WP_000958598.1 putative quinol monooxygenase -
MOO21_RS03530 (727651) 727651..728232 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MOO21_RS03535 (728551) 728551..728883 + 333 WP_000917684.1 DUF2645 family protein -
MOO21_RS03540 (728929) 728929..730278 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
MOO21_RS03545 (730275) 730275..730934 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MOO21_RS03550 (731086) 731086..731478 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MOO21_RS03555 (731531) 731531..732013 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MOO21_RS03560 (732218) 732218..732514 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MOO21_RS03565 (732516) 732516..732911 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MOO21_RS03570 (733044) 733044..734651 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MOO21_RS03575 (734789) 734789..737047 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T252165 WP_000415584.1 NZ_CP101513:732218-732514 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT252165 WP_000650107.1 NZ_CP101513:732516-732911 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References