Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2542650..2543285 Replicon chromosome
Accession NC_015460
Organism Gallibacterium anatis UMN179

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag UMN179_RS11870 Protein ID WP_043885296.1
Coordinates 2542980..2543285 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag UMN179_RS11865 Protein ID WP_013747135.1
Coordinates 2542650..2542970 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UMN179_RS11830 2537865..2538557 + 693 WP_013747128.1 phage antirepressor KilAC domain-containing protein -
UMN179_RS12725 2538554..2539351 + 798 WP_013747129.1 hypothetical protein -
UMN179_RS11840 2539351..2540022 + 672 WP_013747130.1 Replication protein P -
UMN179_RS11845 2540031..2540585 + 555 WP_013747131.1 N-6-adenine methyltransferase -
UMN179_RS11850 2540575..2541000 + 426 WP_013747132.1 recombination protein NinB -
UMN179_RS11855 2541031..2541711 - 681 WP_013747133.1 hypothetical protein -
UMN179_RS13235 2541987..2542151 + 165 WP_021460868.1 hypothetical protein -
UMN179_RS11860 2542117..2542578 - 462 WP_013747134.1 hypothetical protein -
UMN179_RS11865 2542650..2542970 - 321 WP_013747135.1 HigA family addiction module antidote protein Antitoxin
UMN179_RS11870 2542980..2543285 - 306 WP_043885296.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
UMN179_RS11875 2543368..2543598 + 231 WP_013747137.1 recombination protein NinG -
UMN179_RS11880 2543649..2543891 + 243 WP_013745252.1 IS3 family transposase -
UMN179_RS11885 2543946..2544758 + 813 WP_043885297.1 IS3 family transposase -
UMN179_RS12985 2544774..2545151 + 378 Protein_2327 recombination protein NinG -
UMN179_RS11895 2545151..2545555 + 405 WP_013747139.1 hypothetical protein -
UMN179_RS11900 2545604..2545879 + 276 WP_013747140.1 type II toxin-antitoxin system RelE/ParE family toxin -
UMN179_RS11905 2545891..2546175 + 285 WP_013747141.1 HigA family addiction module antidote protein -
UMN179_RS13140 2546326..2546409 + 84 Protein_2331 phage holin, lambda family -
UMN179_RS11910 2546712..2547506 + 795 WP_148234060.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2528672..2594330 65658


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12080.81 Da        Isoelectric Point: 9.2789

>T25216 WP_043885296.1 NC_015460:c2543285-2542980 [Gallibacterium anatis UMN179]
MFNLTAKHFKDDYLYRFFQYGEAHSKIPSNLTNVLARKLDMINAAENLNDLRVPPANHLELLEPKENKFYSIRVNKQYRL
IFHFENGKISQLQLDPHRYDL

Download         Length: 306 bp

>T25216 NC_015460:c2543285-2542980 [Gallibacterium anatis UMN179]
ATGTTTAATCTAACGGCAAAACACTTCAAAGATGACTATCTGTATCGCTTCTTCCAATACGGCGAGGCACACAGTAAAAT
CCCCTCTAATCTCACTAACGTATTGGCTAGGAAATTAGATATGATTAATGCAGCAGAAAACCTCAATGATTTACGTGTTC
CGCCAGCTAACCATCTTGAATTGCTTGAGCCTAAAGAAAACAAGTTCTACTCCATTCGTGTCAATAAACAATATCGCCTT
ATTTTTCATTTTGAGAATGGCAAAATTTCTCAATTACAACTCGATCCTCATCGTTACGATTTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11988.85 Da        Isoelectric Point: 7.3201

>AT25216 WP_013747135.1 NC_015460:c2542970-2542650 [Gallibacterium anatis UMN179]
MQTMQRKPTSVGEILFEEFLEPLNLKIGDLADILDVHRNTASGLINNRTKVTLEMAVKLAKAFGTTPEFWLNLQTNVDLW
ELNHNTRFQQSLSKVKVANHALTLAV

Download         Length: 321 bp

>AT25216 NC_015460:c2542970-2542650 [Gallibacterium anatis UMN179]
ATGCAAACAATGCAACGTAAACCTACTTCTGTTGGAGAAATTCTCTTTGAAGAATTTCTAGAACCGCTTAATCTAAAGAT
TGGCGATCTTGCTGACATTCTTGATGTACATCGCAACACCGCCAGCGGCTTGATCAACAATCGCACCAAAGTCACTTTAG
AAATGGCGGTTAAGCTGGCAAAAGCCTTTGGAACAACACCCGAATTTTGGCTTAATCTACAAACCAATGTTGACTTATGG
GAACTTAACCATAACACTCGCTTTCAACAAAGTTTAAGTAAAGTCAAAGTCGCCAATCACGCCTTAACACTTGCTGTTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References