Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3820972..3821565 Replicon chromosome
Accession NZ_CP101417
Organism Xanthomonas hortorum strain jj2001

Toxin (Protein)


Gene name higB Uniprot ID V7ZC95
Locus tag NMB96_RS16350 Protein ID WP_023903907.1
Coordinates 3820972..3821256 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMB96_RS16355 Protein ID WP_023903908.1
Coordinates 3821266..3821565 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMB96_RS16325 (NMB96_16310) 3816157..3816465 - 309 WP_023903904.1 STAS domain-containing protein -
NMB96_RS16330 (NMB96_16315) 3816569..3817819 - 1251 WP_023903905.1 chemotaxis protein CheW -
NMB96_RS16335 (NMB96_16320) 3817816..3818598 - 783 WP_006452730.1 ParA family protein -
NMB96_RS16340 (NMB96_16325) 3818600..3819574 - 975 WP_023903906.1 flagellar motor protein MotD -
NMB96_RS16345 (NMB96_16330) 3819582..3820322 - 741 WP_006452732.1 flagellar motor protein -
NMB96_RS16350 (NMB96_16335) 3820972..3821256 + 285 WP_023903907.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMB96_RS16355 (NMB96_16340) 3821266..3821565 + 300 WP_023903908.1 HigA family addiction module antitoxin Antitoxin
NMB96_RS16360 (NMB96_16345) 3821715..3822425 - 711 Protein_3199 chemotaxis protein CheW -
NMB96_RS16365 (NMB96_16350) 3823126..3826281 + 3156 WP_255085282.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-88)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10724.18 Da        Isoelectric Point: 7.9183

>T252145 WP_023903907.1 NZ_CP101417:3820972-3821256 [Xanthomonas hortorum]
MIQSFRCKHTRALFEGASPRQFRSMQAAAERKLQLLDSAQTLEFLRSPPGNRLELLAGTRAGQHSISISINDQWRVCFVW
TDAGPEHVEIVDYH

Download         Length: 285 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10903.58 Da        Isoelectric Point: 10.7753

>AT252145 WP_023903908.1 NZ_CP101417:3821266-3821565 [Xanthomonas hortorum]
MRLTNKLRAIHPGEILREDFMLPLGLTINGLARALDVPATRIHSIVHGERAISADTAARLARHFGGDAASWLALQATYEL
KTLPNRSEIERNVQPRVAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6V7EJM6

Antitoxin

Source ID Structure

References