Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1506648..1507237 Replicon chromosome
Accession NZ_CP101417
Organism Xanthomonas hortorum strain jj2001

Toxin (Protein)


Gene name graT Uniprot ID V7Z6D6
Locus tag NMB96_RS06340 Protein ID WP_023905806.1
Coordinates 1506648..1506929 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMB96_RS06345 Protein ID WP_006449989.1
Coordinates 1506947..1507237 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMB96_RS06325 (NMB96_06310) 1503253..1504233 - 981 WP_183086757.1 IS5 family transposase -
NMB96_RS06330 (NMB96_06315) 1504286..1505536 - 1251 WP_043889786.1 XopAP family type III secretion system effector -
NMB96_RS06335 (NMB96_06320) 1505601..1505885 - 285 WP_104552355.1 hypothetical protein -
NMB96_RS06340 (NMB96_06325) 1506648..1506929 + 282 WP_023905806.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMB96_RS06345 (NMB96_06330) 1506947..1507237 + 291 WP_006449989.1 HigA family addiction module antitoxin Antitoxin
NMB96_RS06350 (NMB96_06335) 1507420..1507610 - 191 Protein_1250 hypothetical protein -
NMB96_RS06355 (NMB96_06340) 1507764..1508096 - 333 WP_183086954.1 hypothetical protein -
NMB96_RS06360 (NMB96_06345) 1508653..1509060 + 408 WP_104592032.1 hypothetical protein -
NMB96_RS06365 (NMB96_06350) 1509095..1510249 + 1155 WP_023905258.1 hypothetical protein -
NMB96_RS06370 (NMB96_06355) 1510364..1510696 - 333 WP_255086512.1 hypothetical protein -
NMB96_RS06375 (NMB96_06360) 1510823..1511569 - 747 WP_255086513.1 RelA/SpoT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1494518..1536315 41797
- flank IS/Tn - - 1503253..1504233 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11071.73 Da        Isoelectric Point: 9.7972

>T252141 WP_023905806.1 NZ_CP101417:1506648-1506929 [Xanthomonas hortorum]
MIRSFVDKEAEKIWQGERSRRLPADIQPVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10540.20 Da        Isoelectric Point: 6.4664

>AT252141 WP_006449989.1 NZ_CP101417:1506947-1507237 [Xanthomonas hortorum]
MTVLPNIHPGEILLEEFLEPMGISQNALARATDVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6V7FNW3

Antitoxin

Source ID Structure

References