Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4781264..4781866 Replicon chromosome
Accession NZ_CP101390
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NMU39_RS23460 Protein ID WP_001159630.1
Coordinates 4781555..4781866 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMU39_RS23455 Protein ID WP_000362050.1
Coordinates 4781264..4781554 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS23440 (4778757) 4778757..4779659 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NMU39_RS23445 (4779656) 4779656..4780291 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NMU39_RS23450 (4780288) 4780288..4781217 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NMU39_RS23455 (4781264) 4781264..4781554 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NMU39_RS23460 (4781555) 4781555..4781866 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NMU39_RS23465 (4782084) 4782084..4783013 + 930 WP_001127703.1 alpha/beta hydrolase -
NMU39_RS23470 (4783099) 4783099..4783410 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NMU39_RS23475 (4783407) 4783407..4783853 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NMU39_RS23480 (4783868) 4783868..4784809 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NMU39_RS23485 (4784854) 4784854..4785291 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NMU39_RS23490 (4785288) 4785288..4786160 - 873 WP_000921427.1 virulence factor BrkB family protein -
NMU39_RS23495 (4786154) 4786154..4786753 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T252130 WP_001159630.1 NZ_CP101390:c4781866-4781555 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT252130 WP_000362050.1 NZ_CP101390:c4781554-4781264 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References