Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2527488..2528010 Replicon chromosome
Accession NZ_CP101390
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU39_RS12485 Protein ID WP_000221343.1
Coordinates 2527726..2528010 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU39_RS12480 Protein ID WP_000885424.1
Coordinates 2527488..2527736 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS12455 (2522704) 2522704..2524170 + 1467 WP_000987828.1 hypothetical protein -
NMU39_RS12460 (2524978) 2524978..2525692 + 715 Protein_2439 helix-turn-helix domain-containing protein -
NMU39_RS12465 (2525748) 2525748..2526656 - 909 WP_010989018.1 hypothetical protein -
NMU39_RS12470 (2526799) 2526799..2527131 - 333 WP_000253154.1 DUF1493 family protein -
NMU39_RS12475 (2527121) 2527121..2527336 - 216 WP_000206207.1 hypothetical protein -
NMU39_RS12480 (2527488) 2527488..2527736 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU39_RS12485 (2527726) 2527726..2528010 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU39_RS12490 (2528181) 2528181..2528570 + 390 WP_000194089.1 RidA family protein -
NMU39_RS12495 (2528622) 2528622..2529701 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU39_RS12500 (2529894) 2529894..2530382 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU39_RS12505 (2530427) 2530427..2531935 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2522707..2534792 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T252123 WP_000221343.1 NZ_CP101390:2527726-2528010 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252123 WP_000885424.1 NZ_CP101390:2527488-2527736 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References