Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4807124..4807878 | Replicon | chromosome |
| Accession | NZ_CP101388 | ||
| Organism | Salmonella enterica strain SC2017167 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | NMU38_RS23585 | Protein ID | WP_000558166.1 |
| Coordinates | 4807124..4807435 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NMU38_RS23590 | Protein ID | WP_001259011.1 |
| Coordinates | 4807432..4807878 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NMU38_RS23555 (4802782) | 4802782..4803684 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| NMU38_RS23560 (4803681) | 4803681..4804316 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| NMU38_RS23565 (4804313) | 4804313..4805242 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| NMU38_RS23570 (4805289) | 4805289..4805579 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| NMU38_RS23575 (4805580) | 4805580..4805891 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| NMU38_RS23580 (4806109) | 4806109..4807038 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
| NMU38_RS23585 (4807124) | 4807124..4807435 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NMU38_RS23590 (4807432) | 4807432..4807878 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| NMU38_RS23595 (4807893) | 4807893..4808834 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| NMU38_RS23600 (4808879) | 4808879..4809316 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| NMU38_RS23605 (4809313) | 4809313..4810185 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
| NMU38_RS23610 (4810179) | 4810179..4810778 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| NMU38_RS23615 (4810969) | 4810969..4811772 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| NMU38_RS23620 (4811806) | 4811806..4812702 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T252111 WP_000558166.1 NZ_CP101388:4807124-4807435 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT252111 WP_001259011.1 NZ_CP101388:4807432-4807878 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|