252103

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2471577..2472099 Replicon chromosome
Accession NZ_CP101388
Organism Salmonella enterica strain SC2017167

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU38_RS12175 Protein ID WP_000221343.1
Coordinates 2471815..2472099 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU38_RS12170 Protein ID WP_000885424.1
Coordinates 2471577..2471825 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU38_RS12145 (2466793) 2466793..2468259 + 1467 WP_000987828.1 hypothetical protein -
NMU38_RS12150 (2469067) 2469067..2469781 + 715 Protein_2377 helix-turn-helix domain-containing protein -
NMU38_RS12155 (2469837) 2469837..2470745 - 909 WP_010989018.1 hypothetical protein -
NMU38_RS12160 (2470888) 2470888..2471220 - 333 WP_000253154.1 DUF1493 family protein -
NMU38_RS12165 (2471210) 2471210..2471425 - 216 WP_000206207.1 hypothetical protein -
NMU38_RS12170 (2471577) 2471577..2471825 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU38_RS12175 (2471815) 2471815..2472099 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU38_RS12180 (2472270) 2472270..2472659 + 390 WP_000194089.1 RidA family protein -
NMU38_RS12185 (2472711) 2472711..2473790 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU38_RS12190 (2473983) 2473983..2474471 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU38_RS12195 (2474516) 2474516..2476024 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2466796..2478881 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T252103 WP_000221343.1 NZ_CP101388:2471815-2472099 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252103 WP_000885424.1 NZ_CP101388:2471577-2471825 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References