Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4776576..4777178 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NMU37_RS23425 Protein ID WP_001159630.1
Coordinates 4776867..4777178 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMU37_RS23420 Protein ID WP_000362050.1
Coordinates 4776576..4776866 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS23405 (4774069) 4774069..4774971 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NMU37_RS23410 (4774968) 4774968..4775603 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NMU37_RS23415 (4775600) 4775600..4776529 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NMU37_RS23420 (4776576) 4776576..4776866 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NMU37_RS23425 (4776867) 4776867..4777178 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NMU37_RS23430 (4777396) 4777396..4778325 + 930 WP_001127703.1 alpha/beta hydrolase -
NMU37_RS23435 (4778411) 4778411..4778722 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NMU37_RS23440 (4778719) 4778719..4779165 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NMU37_RS23445 (4779180) 4779180..4780121 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NMU37_RS23450 (4780166) 4780166..4780603 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NMU37_RS23455 (4780600) 4780600..4781472 - 873 WP_000921427.1 virulence factor BrkB family protein -
NMU37_RS23460 (4781466) 4781466..4782065 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T252090 WP_001159630.1 NZ_CP101386:c4777178-4776867 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT252090 WP_000362050.1 NZ_CP101386:c4776866-4776576 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References