252083

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2521723..2522245 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU37_RS12450 Protein ID WP_000221343.1
Coordinates 2521961..2522245 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU37_RS12445 Protein ID WP_000885424.1
Coordinates 2521723..2521971 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS12420 (2516939) 2516939..2518405 + 1467 WP_000987828.1 hypothetical protein -
NMU37_RS12425 (2519213) 2519213..2519927 + 715 Protein_2432 helix-turn-helix domain-containing protein -
NMU37_RS12430 (2519983) 2519983..2520891 - 909 WP_010989018.1 hypothetical protein -
NMU37_RS12435 (2521034) 2521034..2521366 - 333 WP_000253154.1 DUF1493 family protein -
NMU37_RS12440 (2521356) 2521356..2521571 - 216 WP_000206207.1 hypothetical protein -
NMU37_RS12445 (2521723) 2521723..2521971 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU37_RS12450 (2521961) 2521961..2522245 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU37_RS12455 (2522416) 2522416..2522805 + 390 WP_000194089.1 RidA family protein -
NMU37_RS12460 (2522857) 2522857..2523936 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU37_RS12465 (2524129) 2524129..2524617 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU37_RS12470 (2524662) 2524662..2526170 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2516942..2529027 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T252083 WP_000221343.1 NZ_CP101386:2521961-2522245 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252083 WP_000885424.1 NZ_CP101386:2521723-2521971 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References