Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4761061..4761663 Replicon chromosome
Accession NZ_CP101382
Organism Salmonella enterica strain SC2017030

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NMU36_RS23340 Protein ID WP_001159630.1
Coordinates 4761352..4761663 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMU36_RS23335 Protein ID WP_000362050.1
Coordinates 4761061..4761351 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU36_RS23320 (4758554) 4758554..4759456 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NMU36_RS23325 (4759453) 4759453..4760088 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NMU36_RS23330 (4760085) 4760085..4761014 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NMU36_RS23335 (4761061) 4761061..4761351 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NMU36_RS23340 (4761352) 4761352..4761663 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NMU36_RS23345 (4761881) 4761881..4762810 + 930 WP_001127703.1 alpha/beta hydrolase -
NMU36_RS23350 (4762896) 4762896..4763207 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NMU36_RS23355 (4763204) 4763204..4763650 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NMU36_RS23360 (4763665) 4763665..4764606 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NMU36_RS23365 (4764651) 4764651..4765088 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NMU36_RS23370 (4765085) 4765085..4765957 - 873 WP_000921427.1 virulence factor BrkB family protein -
NMU36_RS23375 (4765951) 4765951..4766550 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T252070 WP_001159630.1 NZ_CP101382:c4761663-4761352 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT252070 WP_000362050.1 NZ_CP101382:c4761351-4761061 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References