Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2508345..2508867 Replicon chromosome
Accession NZ_CP101382
Organism Salmonella enterica strain SC2017030

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU36_RS12370 Protein ID WP_000221343.1
Coordinates 2508583..2508867 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU36_RS12365 Protein ID WP_000885424.1
Coordinates 2508345..2508593 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU36_RS12340 (2503561) 2503561..2505027 + 1467 WP_000987828.1 hypothetical protein -
NMU36_RS12345 (2505835) 2505835..2506549 + 715 Protein_2416 helix-turn-helix domain-containing protein -
NMU36_RS12350 (2506605) 2506605..2507513 - 909 WP_010989018.1 hypothetical protein -
NMU36_RS12355 (2507656) 2507656..2507988 - 333 WP_000253154.1 DUF1493 family protein -
NMU36_RS12360 (2507978) 2507978..2508193 - 216 WP_000206207.1 hypothetical protein -
NMU36_RS12365 (2508345) 2508345..2508593 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU36_RS12370 (2508583) 2508583..2508867 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU36_RS12375 (2509038) 2509038..2509427 + 390 WP_000194089.1 RidA family protein -
NMU36_RS12380 (2509479) 2509479..2510558 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU36_RS12385 (2510751) 2510751..2511239 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU36_RS12390 (2511284) 2511284..2512792 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2503564..2515649 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T252063 WP_000221343.1 NZ_CP101382:2508583-2508867 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252063 WP_000885424.1 NZ_CP101382:2508345-2508593 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References