Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4800766..4801368 Replicon chromosome
Accession NZ_CP101379
Organism Salmonella enterica strain SC2016290

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NMU35_RS23595 Protein ID WP_001159630.1
Coordinates 4801057..4801368 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMU35_RS23590 Protein ID WP_000362050.1
Coordinates 4800766..4801056 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU35_RS23575 (4798259) 4798259..4799161 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NMU35_RS23580 (4799158) 4799158..4799793 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NMU35_RS23585 (4799790) 4799790..4800719 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NMU35_RS23590 (4800766) 4800766..4801056 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NMU35_RS23595 (4801057) 4801057..4801368 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NMU35_RS23600 (4801586) 4801586..4802515 + 930 WP_001127703.1 alpha/beta hydrolase -
NMU35_RS23605 (4802601) 4802601..4802912 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NMU35_RS23610 (4802909) 4802909..4803355 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NMU35_RS23615 (4803370) 4803370..4804311 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NMU35_RS23620 (4804356) 4804356..4804793 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NMU35_RS23625 (4804790) 4804790..4805662 - 873 WP_000921427.1 virulence factor BrkB family protein -
NMU35_RS23630 (4805656) 4805656..4806255 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T252047 WP_001159630.1 NZ_CP101379:c4801368-4801057 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT252047 WP_000362050.1 NZ_CP101379:c4801056-4800766 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References