252040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2464789..2465311 Replicon chromosome
Accession NZ_CP101379
Organism Salmonella enterica strain SC2016290

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU35_RS12165 Protein ID WP_000221343.1
Coordinates 2465027..2465311 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU35_RS12160 Protein ID WP_000885424.1
Coordinates 2464789..2465037 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU35_RS12135 (2460005) 2460005..2461471 + 1467 WP_000987828.1 hypothetical protein -
NMU35_RS12140 (2462279) 2462279..2462993 + 715 Protein_2375 helix-turn-helix domain-containing protein -
NMU35_RS12145 (2463049) 2463049..2463957 - 909 WP_010989018.1 hypothetical protein -
NMU35_RS12150 (2464100) 2464100..2464432 - 333 WP_000253154.1 DUF1493 family protein -
NMU35_RS12155 (2464422) 2464422..2464637 - 216 WP_000206207.1 hypothetical protein -
NMU35_RS12160 (2464789) 2464789..2465037 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU35_RS12165 (2465027) 2465027..2465311 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU35_RS12170 (2465482) 2465482..2465871 + 390 WP_000194089.1 RidA family protein -
NMU35_RS12175 (2465923) 2465923..2467002 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU35_RS12180 (2467195) 2467195..2467683 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU35_RS12185 (2467728) 2467728..2469236 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2460008..2478061 18053


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T252040 WP_000221343.1 NZ_CP101379:2465027-2465311 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252040 WP_000885424.1 NZ_CP101379:2464789-2465037 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References