Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4802625..4803227 Replicon chromosome
Accession NZ_CP101376
Organism Salmonella enterica strain SC2016091

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NMU34_RS23560 Protein ID WP_001159630.1
Coordinates 4802916..4803227 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMU34_RS23555 Protein ID WP_000362050.1
Coordinates 4802625..4802915 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU34_RS23540 (4800118) 4800118..4801020 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NMU34_RS23545 (4801017) 4801017..4801652 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NMU34_RS23550 (4801649) 4801649..4802578 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NMU34_RS23555 (4802625) 4802625..4802915 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NMU34_RS23560 (4802916) 4802916..4803227 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NMU34_RS23565 (4803445) 4803445..4804374 + 930 WP_001127703.1 alpha/beta hydrolase -
NMU34_RS23570 (4804460) 4804460..4804771 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NMU34_RS23575 (4804768) 4804768..4805214 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NMU34_RS23580 (4805229) 4805229..4806170 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NMU34_RS23585 (4806215) 4806215..4806652 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NMU34_RS23590 (4806649) 4806649..4807521 - 873 WP_000921427.1 virulence factor BrkB family protein -
NMU34_RS23595 (4807515) 4807515..4808114 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T252024 WP_001159630.1 NZ_CP101376:c4803227-4802916 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT252024 WP_000362050.1 NZ_CP101376:c4802915-4802625 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References