Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2469483..2470005 Replicon chromosome
Accession NZ_CP101376
Organism Salmonella enterica strain SC2016091

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU34_RS12160 Protein ID WP_000221343.1
Coordinates 2469721..2470005 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU34_RS12155 Protein ID WP_000885424.1
Coordinates 2469483..2469731 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU34_RS12130 (2464699) 2464699..2466165 + 1467 WP_000987828.1 hypothetical protein -
NMU34_RS12135 (2466973) 2466973..2467687 + 715 Protein_2374 helix-turn-helix domain-containing protein -
NMU34_RS12140 (2467743) 2467743..2468651 - 909 WP_010989018.1 hypothetical protein -
NMU34_RS12145 (2468794) 2468794..2469126 - 333 WP_000253154.1 DUF1493 family protein -
NMU34_RS12150 (2469116) 2469116..2469331 - 216 WP_000206207.1 hypothetical protein -
NMU34_RS12155 (2469483) 2469483..2469731 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU34_RS12160 (2469721) 2469721..2470005 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU34_RS12165 (2470176) 2470176..2470565 + 390 WP_000194089.1 RidA family protein -
NMU34_RS12170 (2470617) 2470617..2471696 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU34_RS12175 (2471889) 2471889..2472377 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU34_RS12180 (2472422) 2472422..2473930 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2464702..2476787 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T252017 WP_000221343.1 NZ_CP101376:2469721-2470005 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252017 WP_000885424.1 NZ_CP101376:2469483-2469731 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References