252000

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 3105644..3106166 Replicon chromosome
Accession NZ_CP101375
Organism Salmonella enterica strain SC2016090

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU33_RS15370 Protein ID WP_000221343.1
Coordinates 3105882..3106166 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU33_RS15365 Protein ID WP_000885424.1
Coordinates 3105644..3105892 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU33_RS15340 (3100860) 3100860..3102326 + 1467 WP_000987828.1 hypothetical protein -
NMU33_RS15345 (3103134) 3103134..3103848 + 715 Protein_2997 helix-turn-helix domain-containing protein -
NMU33_RS15350 (3103904) 3103904..3104812 - 909 WP_010989018.1 hypothetical protein -
NMU33_RS15355 (3104955) 3104955..3105287 - 333 WP_000253154.1 DUF1493 family protein -
NMU33_RS15360 (3105277) 3105277..3105492 - 216 WP_000206207.1 hypothetical protein -
NMU33_RS15365 (3105644) 3105644..3105892 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU33_RS15370 (3105882) 3105882..3106166 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU33_RS15375 (3106337) 3106337..3106726 + 390 WP_000194089.1 RidA family protein -
NMU33_RS15380 (3106778) 3106778..3107857 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU33_RS15385 (3108050) 3108050..3108538 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU33_RS15390 (3108583) 3108583..3110091 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3100863..3112948 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T252000 WP_000221343.1 NZ_CP101375:3105882-3106166 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252000 WP_000885424.1 NZ_CP101375:3105644-3105892 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References