Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1860158..1860677 Replicon chromosome
Accession NC_015433
Organism Streptococcus suis ST3

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag SSUST3_RS09130 Protein ID WP_013730620.1
Coordinates 1860158..1860415 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag SSUST3_RS09135 Protein ID WP_002939010.1
Coordinates 1860417..1860677 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUST3_RS09115 1856629..1858359 - 1731 WP_013730619.1 membrane protein -
SSUST3_RS09120 1858722..1859630 - 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSUST3_RS09125 1859614..1860144 - 531 WP_009910909.1 DUF1697 domain-containing protein -
SSUST3_RS09130 1860158..1860415 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
SSUST3_RS09135 1860417..1860677 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SSUST3_RS09140 1860753..1861208 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
SSUST3_RS09145 1861212..1861580 - 369 WP_013730622.1 hypothetical protein -
SSUST3_RS09150 1861573..1862142 - 570 WP_022540720.1 ribonuclease M5 -
SSUST3_RS09155 1862126..1862908 - 783 WP_002939015.1 TatD family hydrolase -
SSUST3_RS09160 1863016..1863153 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSUST3_RS09165 1863321..1864316 - 996 WP_013730624.1 protein jag -
SSUST3_RS09170 1864336..1865148 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
SSUST3_RS09175 1865132..1865491 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T25200 WP_013730620.1 NC_015433:c1860415-1860158 [Streptococcus suis ST3]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T25200 NC_015433:c1860415-1860158 [Streptococcus suis ST3]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT25200 WP_002939010.1 NC_015433:c1860677-1860417 [Streptococcus suis ST3]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT25200 NC_015433:c1860677-1860417 [Streptococcus suis ST3]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References