Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 113985..114587 Replicon chromosome
Accession NZ_CP101375
Organism Salmonella enterica strain SC2016090

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NMU33_RS00520 Protein ID WP_001159630.1
Coordinates 114276..114587 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMU33_RS00515 Protein ID WP_000362050.1
Coordinates 113985..114275 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU33_RS00500 (111478) 111478..112380 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NMU33_RS00505 (112377) 112377..113012 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NMU33_RS00510 (113009) 113009..113938 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NMU33_RS00515 (113985) 113985..114275 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NMU33_RS00520 (114276) 114276..114587 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NMU33_RS00525 (114805) 114805..115734 + 930 WP_001127703.1 alpha/beta hydrolase -
NMU33_RS00530 (115820) 115820..116131 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NMU33_RS00535 (116128) 116128..116574 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NMU33_RS00540 (116589) 116589..117530 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NMU33_RS00545 (117575) 117575..118012 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NMU33_RS00550 (118009) 118009..118881 - 873 WP_000921427.1 virulence factor BrkB family protein -
NMU33_RS00555 (118875) 118875..119474 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T251987 WP_001159630.1 NZ_CP101375:c114587-114276 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251987 WP_000362050.1 NZ_CP101375:c114275-113985 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References