Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4753933..4754535 Replicon chromosome
Accession NZ_CP101373
Organism Salmonella enterica strain SC2016042

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NMU32_RS23295 Protein ID WP_001159630.1
Coordinates 4754224..4754535 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMU32_RS23290 Protein ID WP_000362050.1
Coordinates 4753933..4754223 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU32_RS23275 (4751426) 4751426..4752328 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NMU32_RS23280 (4752325) 4752325..4752960 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NMU32_RS23285 (4752957) 4752957..4753886 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NMU32_RS23290 (4753933) 4753933..4754223 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NMU32_RS23295 (4754224) 4754224..4754535 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NMU32_RS23300 (4754753) 4754753..4755682 + 930 WP_001127703.1 alpha/beta hydrolase -
NMU32_RS23305 (4755768) 4755768..4756079 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NMU32_RS23310 (4756076) 4756076..4756522 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NMU32_RS23315 (4756537) 4756537..4757478 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NMU32_RS23320 (4757523) 4757523..4757960 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NMU32_RS23325 (4757957) 4757957..4758829 - 873 WP_000921427.1 virulence factor BrkB family protein -
NMU32_RS23330 (4758823) 4758823..4759422 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T251983 WP_001159630.1 NZ_CP101373:c4754535-4754224 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251983 WP_000362050.1 NZ_CP101373:c4754223-4753933 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References