Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2502373..2502895 Replicon chromosome
Accession NZ_CP101373
Organism Salmonella enterica strain SC2016042

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU32_RS12335 Protein ID WP_000221343.1
Coordinates 2502611..2502895 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU32_RS12330 Protein ID WP_000885424.1
Coordinates 2502373..2502621 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU32_RS12305 (2497589) 2497589..2499055 + 1467 WP_000987828.1 hypothetical protein -
NMU32_RS12310 (2499863) 2499863..2500577 + 715 Protein_2409 helix-turn-helix domain-containing protein -
NMU32_RS12315 (2500633) 2500633..2501541 - 909 WP_010989018.1 hypothetical protein -
NMU32_RS12320 (2501684) 2501684..2502016 - 333 WP_000253154.1 DUF1493 family protein -
NMU32_RS12325 (2502006) 2502006..2502221 - 216 WP_000206207.1 hypothetical protein -
NMU32_RS12330 (2502373) 2502373..2502621 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU32_RS12335 (2502611) 2502611..2502895 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU32_RS12340 (2503066) 2503066..2503455 + 390 WP_000194089.1 RidA family protein -
NMU32_RS12345 (2503507) 2503507..2504586 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU32_RS12350 (2504779) 2504779..2505267 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU32_RS12355 (2505312) 2505312..2506820 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2497592..2509677 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251976 WP_000221343.1 NZ_CP101373:2502611-2502895 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251976 WP_000885424.1 NZ_CP101373:2502373-2502621 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References