Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5048067..5048669 Replicon chromosome
Accession NZ_CP101372
Organism Salmonella enterica strain SC2016025

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NMU31_RS24860 Protein ID WP_001159630.1
Coordinates 5048358..5048669 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMU31_RS24855 Protein ID WP_000362050.1
Coordinates 5048067..5048357 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU31_RS24840 (5045560) 5045560..5046462 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NMU31_RS24845 (5046459) 5046459..5047094 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NMU31_RS24850 (5047091) 5047091..5048020 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NMU31_RS24855 (5048067) 5048067..5048357 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NMU31_RS24860 (5048358) 5048358..5048669 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NMU31_RS24865 (5048887) 5048887..5049816 + 930 WP_001127703.1 alpha/beta hydrolase -
NMU31_RS24870 (5049902) 5049902..5050213 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NMU31_RS24875 (5050210) 5050210..5050656 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NMU31_RS24880 (5050671) 5050671..5051612 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NMU31_RS24885 (5051657) 5051657..5052094 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NMU31_RS24890 (5052091) 5052091..5052963 - 873 WP_000921427.1 virulence factor BrkB family protein -
NMU31_RS24895 (5052957) 5052957..5053556 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T251964 WP_001159630.1 NZ_CP101372:c5048669-5048358 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251964 WP_000362050.1 NZ_CP101372:c5048357-5048067 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References