251957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2794387..2794909 Replicon chromosome
Accession NZ_CP101372
Organism Salmonella enterica strain SC2016025

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NMU31_RS13890 Protein ID WP_000221343.1
Coordinates 2794625..2794909 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NMU31_RS13885 Protein ID WP_000885424.1
Coordinates 2794387..2794635 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU31_RS13860 (2789603) 2789603..2791069 + 1467 WP_000987828.1 hypothetical protein -
NMU31_RS13865 (2791877) 2791877..2792591 + 715 Protein_2720 helix-turn-helix domain-containing protein -
NMU31_RS13870 (2792647) 2792647..2793555 - 909 WP_010989018.1 hypothetical protein -
NMU31_RS13875 (2793698) 2793698..2794030 - 333 WP_000253154.1 DUF1493 family protein -
NMU31_RS13880 (2794020) 2794020..2794235 - 216 WP_000206207.1 hypothetical protein -
NMU31_RS13885 (2794387) 2794387..2794635 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMU31_RS13890 (2794625) 2794625..2794909 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU31_RS13895 (2795080) 2795080..2795469 + 390 WP_000194089.1 RidA family protein -
NMU31_RS13900 (2795521) 2795521..2796600 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NMU31_RS13905 (2796793) 2796793..2797281 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NMU31_RS13910 (2797326) 2797326..2798834 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2791351..2801691 10340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251957 WP_000221343.1 NZ_CP101372:2794625-2794909 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251957 WP_000885424.1 NZ_CP101372:2794387-2794635 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References