Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2123071..2123798 | Replicon | chromosome |
| Accession | NZ_CP101369 | ||
| Organism | Salmonella enterica strain SC2014238 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A8E5IJ81 |
| Locus tag | NMU30_RS10690 | Protein ID | WP_000558157.1 |
| Coordinates | 2123487..2123798 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NMU30_RS10685 | Protein ID | WP_000561389.1 |
| Coordinates | 2123071..2123490 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NMU30_RS10660 (2119879) | 2119879..2120420 | + | 542 | Protein_2025 | transposase | - |
| NMU30_RS10665 (2120566) | 2120566..2120706 | - | 141 | WP_001640444.1 | hypothetical protein | - |
| NMU30_RS10670 (2120872) | 2120872..2121141 | - | 270 | WP_077909686.1 | hypothetical protein | - |
| NMU30_RS10675 (2121511) | 2121511..2121930 | + | 420 | WP_023216650.1 | GNAT family N-acetyltransferase | - |
| NMU30_RS10680 (2122166) | 2122166..2122818 | - | 653 | Protein_2029 | glycosyltransferase | - |
| NMU30_RS10685 (2123071) | 2123071..2123490 | - | 420 | WP_000561389.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NMU30_RS10690 (2123487) | 2123487..2123798 | - | 312 | WP_000558157.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NMU30_RS10695 (2123977) | 2123977..2124276 | + | 300 | WP_000775226.1 | hypothetical protein | - |
| NMU30_RS10700 (2124306) | 2124306..2124521 | + | 216 | WP_070793957.1 | hypothetical protein | - |
| NMU30_RS10705 (2124575) | 2124575..2125357 | - | 783 | WP_240890580.1 | DUF2971 domain-containing protein | - |
| NMU30_RS10710 (2125720) | 2125720..2125887 | - | 168 | WP_165850592.1 | hypothetical protein | - |
| NMU30_RS10715 (2126008) | 2126008..2126484 | - | 477 | WP_023138823.1 | hypothetical protein | - |
| NMU30_RS10720 (2126813) | 2126813..2127208 | - | 396 | WP_000422887.1 | DUF1398 domain-containing protein | - |
| NMU30_RS10725 (2127893) | 2127893..2128615 | + | 723 | WP_058820973.1 | SPI-1 type III secretion system guanine nucleotide exchange factor SopE2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2120082..2120420 | 338 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12425.26 Da Isoelectric Point: 10.1376
>T251931 WP_000558157.1 NZ_CP101369:c2123798-2123487 [Salmonella enterica]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15301.49 Da Isoelectric Point: 4.6286
>AT251931 WP_000561389.1 NZ_CP101369:c2123490-2123071 [Salmonella enterica]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|