Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4694003..4694757 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NM059_RS22970 Protein ID WP_000558162.1
Coordinates 4694003..4694314 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NM059_RS22975 Protein ID WP_001259009.1
Coordinates 4694311..4694757 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS22940 (4689661) 4689661..4690563 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NM059_RS22945 (4690560) 4690560..4691195 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
NM059_RS22950 (4691192) 4691192..4692121 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NM059_RS22955 (4692168) 4692168..4692458 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
NM059_RS22960 (4692459) 4692459..4692770 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
NM059_RS22965 (4692988) 4692988..4693917 + 930 WP_001127706.1 alpha/beta hydrolase -
NM059_RS22970 (4694003) 4694003..4694314 + 312 WP_000558162.1 type II toxin-antitoxin system HigB family toxin Toxin
NM059_RS22975 (4694311) 4694311..4694757 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
NM059_RS22980 (4694772) 4694772..4695713 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NM059_RS22985 (4695758) 4695758..4696195 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NM059_RS22990 (4696192) 4696192..4697064 - 873 WP_000921423.1 virulence factor BrkB family protein -
NM059_RS22995 (4697058) 4697058..4697657 - 600 WP_000965695.1 glucose-1-phosphatase -
NM059_RS23000 (4697848) 4697848..4698651 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
NM059_RS23005 (4698685) 4698685..4699581 - 897 WP_001651900.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12358.28 Da        Isoelectric Point: 9.3143

>T251918 WP_000558162.1 NZ_CP101365:4694003-4694314 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT251918 WP_001259009.1 NZ_CP101365:4694311-4694757 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References