Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4694003..4694757 | Replicon | chromosome |
Accession | NZ_CP101365 | ||
Organism | Salmonella enterica strain SC2014107 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | NM059_RS22970 | Protein ID | WP_000558162.1 |
Coordinates | 4694003..4694314 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | NM059_RS22975 | Protein ID | WP_001259009.1 |
Coordinates | 4694311..4694757 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NM059_RS22940 (4689661) | 4689661..4690563 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
NM059_RS22945 (4690560) | 4690560..4691195 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
NM059_RS22950 (4691192) | 4691192..4692121 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
NM059_RS22955 (4692168) | 4692168..4692458 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
NM059_RS22960 (4692459) | 4692459..4692770 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
NM059_RS22965 (4692988) | 4692988..4693917 | + | 930 | WP_001127706.1 | alpha/beta hydrolase | - |
NM059_RS22970 (4694003) | 4694003..4694314 | + | 312 | WP_000558162.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
NM059_RS22975 (4694311) | 4694311..4694757 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
NM059_RS22980 (4694772) | 4694772..4695713 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
NM059_RS22985 (4695758) | 4695758..4696195 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
NM059_RS22990 (4696192) | 4696192..4697064 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
NM059_RS22995 (4697058) | 4697058..4697657 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
NM059_RS23000 (4697848) | 4697848..4698651 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
NM059_RS23005 (4698685) | 4698685..4699581 | - | 897 | WP_001651900.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12358.28 Da Isoelectric Point: 9.3143
>T251918 WP_000558162.1 NZ_CP101365:4694003-4694314 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT251918 WP_001259009.1 NZ_CP101365:4694311-4694757 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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