251917

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4692168..4692770 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NM059_RS22960 Protein ID WP_001159635.1
Coordinates 4692459..4692770 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NM059_RS22955 Protein ID WP_000362050.1
Coordinates 4692168..4692458 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS22940 (4689661) 4689661..4690563 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NM059_RS22945 (4690560) 4690560..4691195 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
NM059_RS22950 (4691192) 4691192..4692121 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NM059_RS22955 (4692168) 4692168..4692458 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NM059_RS22960 (4692459) 4692459..4692770 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NM059_RS22965 (4692988) 4692988..4693917 + 930 WP_001127706.1 alpha/beta hydrolase -
NM059_RS22970 (4694003) 4694003..4694314 + 312 WP_000558162.1 type II toxin-antitoxin system HigB family toxin -
NM059_RS22975 (4694311) 4694311..4694757 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
NM059_RS22980 (4694772) 4694772..4695713 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NM059_RS22985 (4695758) 4695758..4696195 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NM059_RS22990 (4696192) 4696192..4697064 - 873 WP_000921423.1 virulence factor BrkB family protein -
NM059_RS22995 (4697058) 4697058..4697657 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T251917 WP_001159635.1 NZ_CP101365:c4692770-4692459 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251917 WP_000362050.1 NZ_CP101365:c4692458-4692168 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References