251904

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1946811..1947471 Replicon chromosome
Accession NZ_CP101365
Organism Salmonella enterica strain SC2014107

Toxin (Protein)


Gene name higB Uniprot ID A0A623V7Z2
Locus tag NM059_RS09415 Protein ID WP_000269842.1
Coordinates 1946811..1947164 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NM059_RS09420 Protein ID WP_000533827.1
Coordinates 1947169..1947471 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM059_RS09390 (1942876) 1942876..1943631 + 756 WP_001089670.1 multiubiquitin domain-containing protein -
NM059_RS09395 (1943606) 1943606..1944790 + 1185 WP_076741638.1 ThiF family adenylyltransferase -
NM059_RS09400 (1944784) 1944784..1945248 + 465 WP_001660343.1 DUF6527 family protein -
NM059_RS09405 (1945629) 1945629..1946096 + 468 WP_000201266.1 hypothetical protein -
NM059_RS09410 (1946093) 1946093..1946314 + 222 WP_000813787.1 helix-turn-helix transcriptional regulator -
NM059_RS09415 (1946811) 1946811..1947164 + 354 WP_000269842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NM059_RS09420 (1947169) 1947169..1947471 + 303 WP_000533827.1 XRE family transcriptional regulator Antitoxin
NM059_RS09425 (1947977) 1947977..1948861 + 885 WP_000511750.1 integrase domain-containing protein -
NM059_RS09430 (1949730) 1949730..1950992 - 1263 WP_076741637.1 integrase arm-type DNA-binding domain-containing protein -
NM059_RS09440 (1951330) 1951330..1952127 - 798 WP_000598920.1 DgsA anti-repressor MtfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1920777..1960147 39370


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13476.36 Da        Isoelectric Point: 9.9199

>T251904 WP_000269842.1 NZ_CP101365:1946811-1947164 [Salmonella enterica]
VWTIKTTDTFDRWFASLNDTNRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.81 Da        Isoelectric Point: 5.7316

>AT251904 WP_000533827.1 NZ_CP101365:1947169-1947471 [Salmonella enterica]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623V7Z2

Antitoxin

Source ID Structure

References