Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 746429..747122 Replicon chromosome
Accession NZ_CP101310
Organism Escherichia coli strain 99-3311

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NMK62_RS03750 Protein ID WP_000415584.1
Coordinates 746429..746725 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NMK62_RS03755 Protein ID WP_000650107.1
Coordinates 746727..747122 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK62_RS03715 (741478) 741478..741792 - 315 WP_000958598.1 putative quinol monooxygenase -
NMK62_RS03720 (741823) 741823..742404 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NMK62_RS03725 (742762) 742762..743058 + 297 WP_000912118.1 DUF2645 family protein -
NMK62_RS03730 (743140) 743140..744489 - 1350 WP_000673396.1 quorum sensing histidine kinase QseC -
NMK62_RS03735 (744486) 744486..745145 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
NMK62_RS03740 (745297) 745297..745689 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NMK62_RS03745 (745742) 745742..746224 + 483 WP_000183497.1 GyrI-like domain-containing protein -
NMK62_RS03750 (746429) 746429..746725 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NMK62_RS03755 (746727) 746727..747122 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NMK62_RS03760 (747255) 747255..748862 + 1608 WP_001400746.1 ABC transporter substrate-binding protein -
NMK62_RS03765 (749000) 749000..751258 + 2259 WP_001281878.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T251883 WP_000415584.1 NZ_CP101310:746429-746725 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT251883 WP_000650107.1 NZ_CP101310:746727-747122 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References