Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5189858..5190460 Replicon chromosome
Accession NZ_CP101305
Organism Escherichia coli strain 2002-3211

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NMK57_RS26005 Protein ID WP_000897305.1
Coordinates 5190149..5190460 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NMK57_RS26000 Protein ID WP_000356397.1
Coordinates 5189858..5190148 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK57_RS25975 (5185803) 5185803..5186705 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NMK57_RS25980 (5186702) 5186702..5187337 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NMK57_RS25985 (5187334) 5187334..5188263 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NMK57_RS25990 (5188593) 5188593..5188835 - 243 WP_001086388.1 protein YiiF -
NMK57_RS25995 (5189054) 5189054..5189272 - 219 WP_001295676.1 CopG family transcriptional regulator -
NMK57_RS26000 (5189858) 5189858..5190148 - 291 WP_000356397.1 NadS family protein Antitoxin
NMK57_RS26005 (5190149) 5190149..5190460 - 312 WP_000897305.1 hypothetical protein Toxin
NMK57_RS26010 (5190689) 5190689..5191596 + 908 Protein_5085 alpha/beta hydrolase -
NMK57_RS26015 (5191764) 5191764..5192678 - 915 WP_072097029.1 transposase -
NMK57_RS26020 (5192691) 5192691..5193629 - 939 Protein_5087 hypothetical protein -
NMK57_RS26025 (5193993) 5193993..5194934 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NMK57_RS26030 (5194979) 5194979..5195416 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T251877 WP_000897305.1 NZ_CP101305:c5190460-5190149 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT251877 WP_000356397.1 NZ_CP101305:c5190148-5189858 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References