Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 585550..586349 Replicon chromosome
Accession NZ_CP101305
Organism Escherichia coli strain 2002-3211

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NMK57_RS02865 Protein ID WP_000347273.1
Coordinates 585550..586014 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NMK57_RS02870 Protein ID WP_001307405.1
Coordinates 586014..586349 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK57_RS02835 (580551) 580551..580985 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NMK57_RS02840 (581003) 581003..581881 - 879 WP_001341890.1 PTS N-acetylgalactosamine transporter subunit IID -
NMK57_RS02845 (581871) 581871..582650 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NMK57_RS02850 (582661) 582661..583134 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NMK57_RS02855 (583157) 583157..584437 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NMK57_RS02860 (584686) 584686..585495 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
NMK57_RS02865 (585550) 585550..586014 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NMK57_RS02870 (586014) 586014..586349 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NMK57_RS02875 (586498) 586498..588069 - 1572 WP_001273771.1 galactarate dehydratase -
NMK57_RS02880 (588444) 588444..589778 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NMK57_RS02885 (589794) 589794..590564 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T251855 WP_000347273.1 NZ_CP101305:c586014-585550 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT251855 WP_001307405.1 NZ_CP101305:c586349-586014 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References